Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Many survivors suffer from concentration deficit, fatigue, depression and low resistance to effort. These symptoms affect their quality of life, their functional level and have a significant impact on primary health care resources utilisation

A key paradigm in the critical care of patients with severe traumatic brain injury (TBI) is avoidance of physiologic derangements that may contribute to "secondary" brain injury