Mild traumatic brain injury (mTBI), including sport-related concussion, has become a major health issue. Nearly 10% of mTBI patients (aged 0-18 years) are symptomatic with post-concussion syndrome (PCS) three months after injury. Persistent post-concussion symptoms often result in significant disability and family burden. However, the biological explanation for these prolonged PCS symptoms remains unclear.

Traumatic brain injuries mainly afflict young healthy people and are a major public health issue. Damage extent is sometimes so important that victims who initially survive end up living with severe sequelae and significantly altered quality of life.