Traumatic brain injury (TBI) is a major cause of mortality and morbidity. Many survivors suffer from concentration deficit, fatigue, depression and low resistance to effort. These symptoms affect their quality of life, their functional level and have a significant impact on primary health care resources utilisation

Mild traumatic brain injury (mTBI), including sport-related concussion, has become a major health issue. Nearly 10% of mTBI patients (aged 0-18 years) are symptomatic with post-concussion syndrome (PCS) three months after injury. Persistent post-concussion symptoms often result in significant disability and family burden. However, the biological explanation for these prolonged PCS symptoms remains unclear.