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Wheeler, Anne

Location The Hospital for Sick Children City Toronto Contact

Wheeler, Anne

Behaviour and cognition are emergent properties of brain networks. My research has focused on using brain-wide structural and functional imaging to examine these processes, how they go awry in disease states, and how network-based biomarkers can be used to inform prognosis and treatment response. I completed my PhD in 2011 in the Institute of Medical Science at the University of Toronto, where I focused on structural and functional imaging in the rodent brain, combining the mapping of brain networks with behavioural analysis. This was followed by a postdoctoral fellowship at the Centre for Addiction and Mental Health (CAMH) where I employed magnetic resonance brain imaging (MRI) to investigate network-based neuroimaging biomarkers in psychiatric disorders.

As the FedEx Catalyst Scholar in Traumatic Brain Injury research at SickKids Hospital my lab focuses on describing how traumatic injury affects the developing brain using advanced MRI acquisition and processing. We are using brain imaging in patient populations and mouse models to look for biomarkers of brain injury in order to describe brain damage and inform prognosis. MRI based biomarkers derived from recent advanced acquisition methods may be able to detect subtle injury induced microscopic alterations in the brain. We are particularly interested in psychiatric outcomes of TBI and how genes influence brain structure and interact with injury to predict outcome.

My research has received support from CIHR and The Brain and Behavior Research Foundation (NARSAD).